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KMID : 0984720050370020099
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Infection and Chemotherapy
2005 Volume.37 No. 2 p.99 ~ p.103
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The efficacy of Oral Levofloxacin in the Treatment of Patient with Chronic Prostatitis
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Oh Chang-Soo
Cheon Sang-Hyeon
Park Ro-Jung
Lee Mi-Suk
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Abstract
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Purpose: Antibiotic is widely used in the treatment of chronic prostatitis. In this study, we evaluated the clinical efficacy and safety of levofloxacin (Cravit^®) in the treatment of patients with chronic prostatitis.
Materials and Methods: Between March 2001 and February 2003, 64 patients with chronic bacterial (NIH-category Ⅱ) and nonbacterial inflammatory prostatitis (NIH-category Ⅲa) were enrolled in this study. Daily 400 mg of levofloxacin was administered orally for 4-18 weeks. To determine the efficacy of levofloxacin, patients were assessed with the NIH-CPSI and examined of expressed prostatic secretion (EPS) at 3 months follow-up period.
Results: The CPSI of 16 patients stratified into NIH-category Ⅱ was 24.9±4.7 before and 14.1±6.5 after the treatment. For 48 patients stratified into NIH-category Ⅲa, the CPSI value before and after the treatment was 23.9±4.4 and 13.2±5.7, respectively. 40 patients (62.5%) showed mild to moderate improvement in NIH-CPSI, and 23 patients (35.9%) showed improvement in the laboratory profile according to the count of leukocytes (WBC <10/HPF) in EPS. Adverse reaction was noted in 1 patient during the treatment.
Conclusions: This study shows that levofloxacin may be a safe and effective agent in treating either chronic bacterial prostatitis or chronic nonbacterial inflammatory prostatitis with few adverse reactions
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KEYWORD
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Chronic inflammatory prostatitis, Levofloxacin, Efficacy
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